What is the future of periodontal regeneration?

[摘要] Periodontitis is an inflammatory disease of bacterial etiology that results in host-mediated destruction of the supporting tissues of the teeth, including connective tissue attachment and bone. Clinically, periodontitis is difficult to treat with a high rate of recurrence. Regeneration of hard and soft tissues lost to disease is limited and not predictable.[24,27,33] The classic tissue engineering triad (cells, mediators, and scaffold) is missing a critical component — the control of inflammation. Tissue regeneration cannot occur in the presence of uncontrolled local inflammation.