Histopathological changes in kidney, Adrenal gland and Skin due to the Effect of Captopril in Mice

[摘要] The present study project was on toxic pathology of captopril (antihypertension drug). The study was done on 44 white mice of 1-1.5 months old (males and females), the mice were divided into four equal groups of 10 mice (5 of each sex), for 6 months. The groups included: untreated control, low therapeutic dose( 2.1 mg / kg), intermediate dose( 6.3 mg / kg) and high dose (toxic) 18.9 mg / kg, daily for 6 months . In addition a peracute high toxicity group treated at 56.7 mg/kg day, dosage level for two weeks (2 males and 2 females). Histopathological examination showed that captopril affected certain visceral organs as target organs, such as kidney which showed dilated cortical tubules, adrenal gland with evidence of reduced size of medulla and angioedema of the lip region and areas of thickened epidermal layer.

[学科分类] 土木及结构工程学