Data analysis to modeling to building theory in NK cell biology and beyond: How can computational modeling contribute?

[摘要] The use of mathematical and computational tools in investigating Natural Killer (NK) cell biology and in general the immune system has increased steadily in the last few decades. However, unlike the physical sciences, there is a persistent ambivalence, which however is increasingly diminishing, in the biology community toward appreciating the utility of quantitative tools in addressing questions of biological importance. We survey some of the recent developments in the application of quantitative approaches for investigating different problems in NK cell biology and evaluate opportunities and challenges of using quantitative methods in providing biological insights in NK cell biology.

[学科分类] 生理学

[关键词] CyTOF;data-driven modeling;mathematical modeling;single cell measurements;single cell trajectory;systems immunology