Tepung okra (Albelmoschus esculantus) menurunkan rasio kadar LDL terhadap HDL tikus hiperkolesterolemiaDOI : 10.21927/ijnd.2017.5(1).17-22 | Abstract views : 757 times

[摘要] Backgounds: Hypercholesterolemia is one cause of heart disease with high levels of Low Density Lipoprotein (LDL) cholesterol and low levels of high density lipoprotein (HDL) cholesterol. Okra ( A lbelmoschus esculantus) flour contain high fibers and more bioactive compound such as flavonoids. Objectives: This study aimed to examine the effect iveness of okra flour against the Low Density Lipoprotein (LDL) cholesterol level and high density lipoprotein (HDL) cholesterol level in Hypercholesterole mic rats. Methods: Design of the study was experimental design with pre-and posttest control goup . Male white rats (rattus norvegicus) aged 8-10 weeks with body weight of 150-200 g were used, then divided into 4 goups of 8 rats.  Rats made Hypercholesterolemia used Haight Fat Diet (HFD) feed at a doses 4mg/100 g body weight for 14 days. After that , Hypercholesterolemic rats were provided by standard diet rats given standart feed and okra flour with different doses it was goups positive control (KP) not given flour okra, okra flour doses 0.09 g/200 g bofy weight (P1) , okra flour doses 0. 18 g/200 g body weight (P2), and okra flour doses 0. 36 g/200 g body weight (P3). The data was analyzed using One Way ANOVA dan paired t-test . Results: Rats in all goup did not experience changes in body weight significantly. Concentration of HDL cholesterol  increase d significantly in P3 goups with doses okra flour 0.36  g/200 g body weight compared with the other goups. P3 goups attenuated the conc entration of LDL cholesterol. Conclusions: the administration okra flour (albelmoschus esculantus) at doses 0.36 g/200 g body weight improve d HDL cholesterol and decrease d LDL cholesterol concentration in Hypercholesterolemi c rat s model.

[关键词] Hypercholesterolemic High Density Lipoprotein (HDL);Low Density Lipoprotein (LDL);Okra Flour;Hiperkolestrolemia;High Density Lipoprotein (HDL);Low Density Lipoprotein (LDL);tepung okra