The role of alpha defensin in prosthetic joint infection (PJI) diagnosis: a literature review

[摘要] Prosthetic joint infections (PJI) occur in 0.7% to 2.4% of patients and are responsible for 15% of failed total hip arthroplasties and 25% of revision total knee arthroplasties.1,2 Almost any microorganism can cause PJI, such as Gram-positive bacteria (accounting for about two-thirds of the total number of infections), Gram-negative bacteria and polymicrobic flora (accounting for about 10–15% of infections each), and fungi (rare).3–5 The management of infections is not standardized worldwide and the outcome is frequently unsatisfactory because of the increasing number of highly virulent and antibiotic-resistant bacteria, and due to an ageing patient population presenting with many comorbidities.

[学科分类] 神经科学

[关键词] alpha defensin;PJI;prosthetic joint infections;synovial biomarkers