Impact of inter-pregnancy interval on long-term endo-metabolic health of the offspring

[摘要] Background:  Inter-pregnancy interval (IPI), defined as the time interval between a live birth and estimated conception time of a subsequent pregnancy, has an established effect on perinatal outcome. The long-term impact of IPI on offspring is unknown. This study aimed to examine the effect of short and long IPIs on long-term endo-metabolic health of offspring. Subjects and Method:  This population-based cohort study included singleton live births in parturient with at least one previous birth. Singleton deliveries between the years 1991-2014 in a regional tertiary medical center were included. Offspring were followed until 18 years of age for endo-metabolic related hospitalizations. Survival curves were used to compare cumulative incidence of endo-metabolic morbidity, and Cox proportional hazards models to control for confounders. Results:  During the study period 144,397 deliveries met the inclusion criteria. Offspring following long IPIs exhibited higher rates of endo-metabolic related hospitalizations. Survival curve demonstrated a significantly higher cumulative incidence of endo-metabolic morbidity in the long IPI group (p<0.001). The Cox model demonstrated long IPI to significantly increase the risk for endo-metabolic related hospitalizations during childhood (aHR= 1.34, 95%CI= 1.06 to 1.70; p=0.015). Conclusion:  Long IPI appears to have an independent impact on long-term endo-metabolic health of the offspring.

[学科分类] 食品科学和技术

[关键词] pregnancy interval;offspring;endocrine health;metabolic morbidity;obesity