Meta-Analysis of the Effect of Prenatal Stress on the Premature Birth

[摘要] Background: Premature birth is a major global public health problem, especially in developing countries. One of the causes of this incident is exposure to psychological stress experienced during pregnancy. This study aims to estimate the magnitude of the effect of prenatal stress on preterm birth using a meta-analysis study. Subjects and Method: The meta-analysis research was conducted by selecting articles published in the years 2006-2020, from the PubMed, Google Scholar, Science Direct, Direc­tory of Open Access (DOAJ), and Springer Link databases. The article search was carried out by considering the eligibility criteria defined using the PICO model. The population in the study were pregnant women with high stress prenatal intervention, comparison with low stress and preterm birth outcomes. This article was collected for 1 month using the following key­words: "Prenatal Stress" AND "Preterm Birth". The inclusion criteria were a free full text study, using English and Indonesian, high stress preg­nant women, observational studies, and the results were reported in the Adjusted Odds Ratio (aOR). The meta-analysis study was carried out with the Review Manager 5.3 program. Results: Meta-analysis of 10 cohort studies showed that pregnant women with high stress were at risk for preterm birth (aOR = 1.35; 95% CI = 1.05 to 1.73; p = 0.02), and 4 case-control studies showed that pregnant women with high stress had a risk for preterm birth (aOR = 2.00; 95% CI = 0.61 to 6.50; p = 0.25). Conclusion: Prenatal stress has a risk of preterm birth.

[学科分类] 食品科学和技术

[关键词] Pregnant women;prenatal stress;preterm birth;meta-analysis