Psychotic aura symptoms in familial hemiplegic migraine type 2 (ATP1A2)

[摘要] IntroductionNeuropsychological symptoms are rare in familial hemiplegic migraine (FHM). There are no reports of psychotic symptoms in FHM type 2 (ATP1A2). We examined a family with a FHM phenotype due to a M731T mutation in ATP1A2. A 10-year follow-up allowed us to observe complex auras, including psychotic symptoms in two siblings.Case reportMale, 48 years old, with an aura that included complex illusions with a feeling of time travelling, coincident with other aura features. The aura was regarded as mystical by the patient. Female, 38 years old, with a complex migraine aura, during which she believed she had the ability to time travel and was being followed by lobbyists who wanted to steal this ability from her.DiscussionFHM type 2 must be included in the list of differential diagnoses of acute psychosis in patients with a previous history of migraine aura.

[发布日期] 2012-06-05

[关键词] ATP1A2 gene;Familial hemiplegic migraine type 2;M731T mutation;Neuropsychological aura;Psychosis;Time travel