已收录 273075 条政策
 政策提纲
  • 暂无提纲
Case Report: COVID-19 Vaccination Associated Fulminant Myocarditis
[摘要] Herein, we describe a novel finding of fulminant myocarditis (FM) in two subjects the day after administration of the first dose of the currently available inactivated SARS-CoV-2 vaccine (Vero cell). Cardiac magnetic resonance imaging revealed extensive myocardial edema and necrosis. A pathologic evaluation of the endocardial biopsy tissues revealed inflammatory cell (lymphocytes) infiltration and interstitial edema, myocyte necrosis, and focal areas of fibrosis. A life-support-based comprehensive treatment regimen comprising mechanical circulatory support using intra-aortic balloon pulsation and immunomodulatory therapy—glucocorticoids and intravenous immunoglobulin—was used to treat the patients with FM; eventually, the patients recovered and were discharged. To our knowledge, these are the first two reported cases of FM, with no other identified cause or associated illness, after receiving the inactivated SARS-CoV-2 vaccine (Vero cell). These findings suggest a novel pathogenesis of myocarditis which mentions to pay more attention to this rare, but lethal complication of COVID-19 vaccination.
[发布日期] 2022-01-24 [发布机构] 
[效力级别]  [学科分类] 
[关键词] myocarditis;COVID-19 vaccine;immunomodulatory therapy;myocyte necrosis;pathogenesis [时效性] 
   浏览次数:2      统一登录查看全文      激活码登录查看全文