Topical Therapeutic Options in Corneal Neuropathic Pain

[摘要] Purpose of Review: Corneal neuropathic pain can be difficult to treat, particularly due to its lack of response to standard dry eye therapies. We describe a variety of topical therapeutic options that are available to treat corneal neuropathic pain with a significant or primary peripheral component. We also describe possible mechanisms of action for such topical therapies.Recent Findings: Topical corticosteroids and blood-derived tear preparations can be helpful. Newer therapies, including topical lacosamide and low-dose naltrexone are emerging therapeutic options that may also be considered.Summary: Corneal neuropathic pain with a significant peripheral component may be managed with a variety of topical therapeutic options.

[发布日期] 2022-01-31

[关键词] corneal neuropathic pain;neuropathic ocular pain;low-dose naltrexone;lacosamide;sub-basal corneal nerve plexus;serum tears