rBahadur: efficient simulation of structured high-dimensional genotype data with applications to assortative mating

[摘要] Existing methods for generating synthetic genotype data are ill-suited for replicating the effects of assortative mating (AM). We propose rb_dplr, a novel and computationally efficient algorithm for generating high-dimensional binary random variates that effectively recapitulates AM-induced genetic architectures using the Bahadur order-2 approximation of the multivariate Bernoulli distribution. The rBahadur R library is available through the Comprehensive R Archive Network at https://CRAN.R-project.org/package=rBahadur.

[发布日期] 2023-08-09

[关键词] Assortative mating;Multivariate Bernoulli;Genotype simulation