Novel Drug Delivery Systems to Enhance Oral Bioavailability and Their Evaluation

[摘要] This review is carried out to understand thedifferent drug delivery systems to enhancetheoral bioavailability of anti-diabetes drug. Diabetes Mellitus is a continual and metabolic issue known to humanity over 2000 years. Solid lipid nanoparticle is one of the Formulation which capable of enhancing oral bioavailability of anti-diabetes drug with less side effect and toxicities.The reasons for poor bioavailability are poor aqueous solubility, first pass metabolism, interaction with food, and degradation in the GIT. Different Novel Formulation are used to improve drug bioavailability are Nanosuspension, Microemulsion, Solid lipid Nanoparticle, Vesicular drug delivery system like, Liposomes and Noisome. The evaluation and characterisation parameters for SLNs are Entrapment efficiency, particle size, zeta potential, invitro release, etc. Solid lipid nanoparticle formulation is very promising method to enhance the oral bioavailability of drug. This review is carried out to understand thedifferent drug delivery systems to enhancetheoral bioavailability of anti-diabetes drug. Diabetes Mellitus is a continual and metabolic issue known to humanity over 2000 years. Solid lipid nanoparticle is one of the Formulation which capable of enhancing oral bioavailability of anti-diabetes drug with less side effect and toxicities.The reasons for poor bioavailability are poor aqueous solubility, first pass metabolism, interaction with food, and degradation in the GIT. Different Novel Formulation are used to improve drug bioavailability are Nanosuspension, Microemulsion, Solid lipid Nanoparticle, Vesicular drug delivery system like, Liposomes and Noisome. The evaluation and characterisation parameters for SLNs are Entrapment efficiency, particle size, zeta potential, invitro release, etc. Solid lipid nanoparticle formulation is very promising method to enhance the oral bioavailability of drug.

[学科分类] 药学、药理学、毒理学（综合）

[关键词] Diabetes Mellitus;Linagliptin;Oral Bioavailability;Solid lipid Nanoparticle.