Formulation and Evaluation of Nanoparticles of Ketoprofen for Transdermal Delivery

[摘要] In the present study, nanoparticles of Ketoprofen for transdermal delivery were prepared and characterized. Nanoparticles were prepared by microemulsification and solvent evaporation method by using different oils at fixed ratio of surfactants and co-surfactant (1:8). Ethanol or acetone was used to dissolve the oils and 10 mg, 20 mg, 30 mg and 40 mg of Ketoprofen was added to each of the formulation. The prepared nanoparticles were evaluated for drug content, particles size, zeta potential, and ex-vivo drug permeability. Oleic acid, glyceryl monostearate (GMS) and cholesterol were used as lipids and span 60 and tween 80 were used as surfactant and co-surfactant respectively. Particle size was found to increase when lipid was changed from oleic acid to GMS and to cholesterol. The ex-vivo permeation study using porcine ear epithelium was carried out. Nanoparticles showed increased permeation when compared to pure drug solution of same concentration indicates oleic acid based nanoparticles open new and interesting perspective as a drug carrier. In the present study, nanoparticles of Ketoprofen for transdermal delivery were prepared and characterized. Nanoparticles were prepared by microemulsification and solvent evaporation method by using different oils at fixed ratio of surfactants and co-surfactant (1:8). Ethanol or acetone was used to dissolve the oils and 10 mg, 20 mg, 30 mg and 40 mg of Ketoprofen was added to each of the formulation. The prepared nanoparticles were evaluated for drug content, particles size, zeta potential, and ex-vivo drug permeability. Oleic acid, glyceryl monostearate (GMS) and cholesterol were used as lipids and span 60 and tween 80 were used as surfactant and co-surfactant respectively. Particle size was found to increase when lipid was changed from oleic acid to GMS and to cholesterol. The ex-vivo permeation study using porcine ear epithelium was carried out. Nanoparticles showed increased permeation when compared to pure drug solution of same concentration indicates oleic acid based nanoparticles open new and interesting perspective as a drug carrier.

[学科分类] 药学、药理学、毒理学（综合）

[关键词] Nanoparticles;Oleic acid;GMS;Cholesterol;Ketoprofen;Microemulsification technique