Formulation and Evaluation of Stability of a Topical Niosomal Gel ContainingCiclopirox Olamine

[摘要] Background: Superficial fungal infections can lead to many complications and serious issues. A diverse range of topical agents such as Ciclopirox olamine (CPO) are available for the treatment of dermatophytes, bacteria, yeasts, and filamentous fungi. CPO is a highly lipophilic drug with very limited systemic absorption. Hence, a specific dosage form of CPO was designed to increase its half-life for providing prolonged drug delivery, as well as minimizing the side effects.Objective: To develop a CPO-containing topical niosomal gel formula and to examine its stability and compatibility with others.Methodology: The prepared niosomal gel was kept in sealed glass containers and preserved under refrigerated and room temperature conditions for 6 months. At the end of the 4th and 8th weeks, and 3rd and 6th months, the samples were collected and tested for various parameters.Results: There were no significant changes in the physicochemical properties such as pH, viscosity, drug content, and release profile.Conclusion: Niosomal gel is stable when refrigerated, as well as at room temperature.Keywords: Ciclopirox, Stability study, Niosomal gel, Fungal infection  Background: Superficial fungal infections can lead to many complications and serious issues. A diverse range of topical agents such as Ciclopirox olamine (CPO) are available for the treatment of dermatophytes, bacteria, yeasts, and filamentous fungi. CPO is a highly lipophilic drug with very limited systemic absorption. Hence, a specific dosage form of CPO was designed to increase its half-life for providing prolonged drug delivery, as well as minimizing the side effects.Objective: To develop a CPO-containing topical niosomal gel formula and to examine its stability and compatibility with others.Methodology: The prepared niosomal gel was kept in sealed glass containers and preserved under refrigerated and room temperature conditions for 6 months. At the end of the 4th and 8th weeks, and 3rd and 6th months, the samples were collected and tested for various parameters.Results: There were no significant changes in the physicochemical properties such as pH, viscosity, drug content, and release profile.Conclusion: Niosomal gel is stable when refrigerated, as well as at room temperature.

[学科分类] 药学、药理学、毒理学（综合）

[关键词] Ciclopirox;Stability study;Niosomal gel;Fungal infection