A Comprehensive Review on the Miracle Nature of Annona muricata Linn

[摘要] This review aims to explore the essence of Annona muricata Linn. A. muricata, frequently called soursop, guanabana and graviola, belongs to the family Annonaceae, and has a long history of traditional uses. This is an evergreen plant found in tropical and subtropical regions of the world, mostly seen in Africa, South America, and South East Asia. The miracle nature of the A. muricata plant is a boon to mankind and has been widely used in folk medicine. Various preparations of A. muricata available in the market include candies, syrups, beverages, ice creams and shakes. Several investigations conclusively report that the plant possesses more than 212 chemical constituents such as acetogenins, alkaloids and phenols. The plant has a wide range of therapeutic effects including antibacterial, antiviral, antifungal, antitumor, anthelminthic, analgesic, antiarthritic, hypotensive, anti-inflammatory, immune enhancing effects, and anti-diabetic activity. The extract of A. muricata is found to be effective and safe, although some reported toxicities cannot be denied. This review attempts to unite most of the available information regarding phytochemistry, traditional uses, biological activities and toxicity related to A. muricata. This review aims to explore the essence of Annona muricata Linn. A. muricata, frequently called soursop, guanabana and graviola, belongs to the family Annonaceae, and has a long history of traditional uses. This is an evergreen plant found in tropical and subtropical regions of the world, mostly seen in Africa, South America, and South East Asia. The miracle nature of the A. muricata plant is a boon to mankind and has been widely used in folk medicine. Various preparations of A. muricata available in the market include candies, syrups, beverages, ice creams and shakes. Several investigations conclusively report that the plant possesses more than 212 chemical constituents such as acetogenins, alkaloids and phenols. The plant has a wide range of therapeutic effects including antibacterial, antiviral, antifungal, antitumor, anthelminthic, analgesic, antiarthritic, hypotensive, anti-inflammatory, immune enhancing effects, and anti-diabetic activity. The extract of A. muricata is found to be effective and safe, although some reported toxicities cannot be denied. This review attempts to unite most of the available information regarding phytochemistry, traditional uses, biological activities and toxicity related to A. muricata.

[学科分类] 药学、药理学、毒理学（综合）

[关键词] Annona muricata;Annonaceae;Annonaceous acetogenins;Cytotoxicity;Neurotoxicity