Paracetamol Induced Toxic Epidermal Necrolysis: A Case Report

[摘要] One of the most commonly used over-the-counter medications for treating fever is Paracetamol. It is generally considered as a safe medicine. However, few extremely uncommon occurrences of Toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS) have been documented in the past and are believed to be connected to Paracetamol use. It is imperative for doctors to be aware of serious unfavourable hypersensitivity reactions that can occur even with medications that are generally believed to be safe, such as Paracetamol. SJS and TEN are both extremely serious hypersensitive reactions that necessitate protracted hospitalisation and intensive care. This case report discusses a similar case of severe hypersensitivity reaction to Paracetamol. One of the most commonly used over-the-counter medications for treating fever is Paracetamol. It is generally considered as a safe medicine. However, few extremely uncommon occurrences of Toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS) have been documented in the past and are believed to be connected to Paracetamol use. It is imperative for doctors to be aware of serious unfavourable hypersensitivity reactions that can occur even with medications that are generally believed to be safe, such as Paracetamol. SJS and TEN are both extremely serious hypersensitive reactions that necessitate protracted hospitalisation and intensive care. This case report discusses a similar case of severe hypersensitivity reaction to Paracetamol.

[学科分类] 药学、药理学、毒理学（综合）

[关键词] Hypersensitivity;Paracetamol;Toxic epidermal necrolysis;Adverse drug reaction;Stevens-Johnsonsyndrome