Development and In Vitro Evaluation of Mucoadhesive Buccal Gels of Betamethasone Sodium Phosphate

[摘要] Betamethasone sodium phosphate is a disodium phosphate salt of 21-phosphate ester of synthetic glucocorticoid: Betamethasone is known to possess immunosuppressant, anti-inflammatory and antifibrolytic properties. Hence, was used in formulation and development of mucoadhesive buccal gel for the treatment of oral submucous fibrosis to facilitate local action and to increase patient compliance. Six formulations were prepared using two different polymers in variable proportions and were subjected for the screening of physicochemical parameters, viz.-homogeneity, grittiness, viscosity, spreadability, extrudability, mucoadhesive strength, pH, drug content uniformity, in vitro drug diffusion, IR spectral analysis and stability studies. Formulation F5 containing 1.25% carboxymethyl cellulose sodium and 1.25% hydroxypropyl methylcellulose resulted with highest drug release and better mucoadhesive strength as compared to the other formulations. Betamethasone sodium phosphate is a disodium phosphate salt of 21-phosphate ester of synthetic glucocorticoid: Betamethasone is known to possess immunosuppressant, anti-inflammatory and antifibrolytic properties. Hence, was used in formulation and development of mucoadhesive buccal gel for the treatment of oral submucous fibrosis to facilitate local action and to increase patient compliance. Six formulations were prepared using two different polymers in variable proportions and were subjected for the screening of physicochemical parameters, viz.-homogeneity, grittiness, viscosity, spreadability, extrudability, mucoadhesive strength, pH, drug content uniformity, in vitro drug diffusion, IR spectral analysis and stability studies. Formulation F5 containing 1.25% carboxymethyl cellulose sodium and 1.25% hydroxypropyl methylcellulose resulted with highest drug release and better mucoadhesive strength as compared to the other formulations.

[学科分类] 药学、药理学、毒理学（综合）

[关键词] Betamethasone sodium phosphate;Oral submucous fibrosis (OSMF);Buccal gels;Mucoadhesion;Carboxymethyl cellulose sodium (Na CMC) and Hydroxypropyl methylcellulose (HPMC).