Evaluation of Protective Effect of Alstonia scholaris Leaf Extract against Lead Induced Hepatotoxicity

[摘要] Lead is widely used which causes occurrence of free lead in the environment. The liver is the major organ and long term exposure to lead may cause severe hepatotoxic effects. The lead induced hepatotoxicity study was performed for the evaluation of hepatoprotective activity of ethanolic leaf extract of Alstonia scholaris against hepatotoxicity induced by lead in wister albino rats. Rats were divided into 4 groups and treated with normal saline, lead acetate, high (300 mg/kg) and low (200 mg/kg) doses of Alstonia scholaris leaf extract along with lead acetate for 8 weeks. Effects of different treatments were evaluated by changes in serum enzymes such as AST, ALT, ALP, total bilirubin and lipid levels were estimated by semi-autoanalyser, antioxidant levels like SOD, Catalase, LPO and GSH activity were measured in liver tissue homogenate and remaining livers were subjected for histopathological studies. Observed results showed dose dependent beneficial effects for Alstonia scholaris leaf extract against lead acetate induced hepatotoxicity. Lead is widely used which causes occurrence of free lead in the environment. The liver is the major organ and long term exposure to lead may cause severe hepatotoxic effects. The lead induced hepatotoxicity study was performed for the evaluation of hepatoprotective activity of ethanolic leaf extract of Alstonia scholaris against hepatotoxicity induced by lead in wister albino rats. Rats were divided into 4 groups and treated with normal saline, lead acetate, high (300 mg/kg) and low (200 mg/kg) doses of Alstonia scholaris leaf extract along with lead acetate for 8 weeks. Effects of different treatments were evaluated by changes in serum enzymes such as AST, ALT, ALP, total bilirubin and lipid levels were estimated by semi-autoanalyser, antioxidant levels like SOD, Catalase, LPO and GSH activity were measured in liver tissue homogenate and remaining livers were subjected for histopathological studies. Observed results showed dose dependent beneficial effects for Alstonia scholaris leaf extract against lead acetate induced hepatotoxicity.

[学科分类] 药学、药理学、毒理学（综合）

[关键词] Alstonia scholaris;hepatotoxicity;lead acetate;lead toxicity.