Estrogen and progesterone in meningioma:Bridging the gap of knowledge

[摘要] Meningiomas are primary central nervous system tumor with the highest prevalence. Meningiomashave a high recurrence rate in the same location. One of the factors thought to be associated with thefrequency of meningiomas is hormonal status. However, research on this subject is still controversial.This review aims to discuss the effect of sex hormones on meningiomas. Sex hormones, especiallyprogesterone, have been shown to play a role in tumorigenesis and meningioma recurrence. Progesteronereceptors also play a role in meningioma recurrence where a low number of receptors indicates a poorprognosis. However, the molecular relationship between meningiomas at low progesterone receptorexpression is still unknown. Further research is still needed to determine the role of sex hormones,especially progesterone, and their receptors, in both tumorigenesis and meningioma progression.This research ensures that new science in the field of endocrinology can be utilized for both primarypreventive, secondary preventive, and therapeutic strategies for meningiomas.

[学科分类] 精神健康和精神病学

[关键词] Progesterone;estrogen;meningioma