Commentary: DO 2 you believe in magic? Promising oxygen delivery-based perfusion strategy for minimizing mild kidney injury in patients undergoing routine cardiac surgery

[摘要] With a reported incidence of 20% to 30%,1,2 acute kidney injury (AKI) is one of the most common complications of cardiopulmonary bypass (CPB). AKI after CPB is likely multifactorial—including ischemia-reperfusion injury, oxidative stress, and microemboli—and ultimately contributes significantly to postoperative mortality.3-5 Each of these is related to successful systemic oxygen delivery (DO2), itself a potential modifiable factor in CPB. Conventional CPB targets are based on body surface area and core body temperature; however, perfusion strategies that modulate pump flows to optimize oxygen delivery (DO2) have been examined as a promising alternative to reduce the risk of perioperative AKI in cardiac surgery.

[学科分类] 心脏病和心血管学