Commentary: Fluoroquinolones and aortopathy—a basic (science) question?

[摘要] The normal human aorta is a sophisticated structure consisting of many cell types embedded in an extracellular matrix, which accounts for its ability to produce laminar flow at high pulsatile stress to offload the intracavitary pressure of the left ventricle and protect organ vascular beds from hypertension.1 To achieve this, the aorta's cellular constituents and extracellular matrix (including elastin and collagen) are normally tightly regulated by a number of interacting pathways, including matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases.

[学科分类] 心脏病和心血管学