Emerging new evidence for the treatment of pulmonary sarcomatoid carcinoma

[摘要] Lung cancer is a leading cause of cancer-related mortality, accounting for 1.8 million people worldwide in 2020 (1). Pulmonary sarcomatoid carcinoma (PSC) is a rare type of non-small cell lung cancer (NSCLC), characterized by poorly differentiated carcinoma with components of sarcoma or sarcoma-like differentiation. The most recent classification of PSC includes pleomorphic carcinoma, giant cell carcinoma, spindle cell carcinoma, pulmonary blastoma, and carcinosarcoma (2). Owing to the rapid advancement in cancer treatment and elucidation of disease mechanisms, the outcomes of lung cancer have drastically improved over the last decade. However, the prognosis of PSC is still poor compared to other forms of NSCLC (3,4). There is limited data regarding the standard treatment strategy, clinical characteristics, and prognostic factors due to the rarity of the disease. Therefore, this necessitates the accumulation of evidence for PSC.

[学科分类] 呼吸医学

[关键词] Treatment;prognostic factor;clinical characteristics;pulmonary sarcomatoid carcinoma (PSC)