A double-edged sword: The HBV-induced non-coding RNAs alterations in hepatocellular carcinoma

[摘要] Non-coding RNAs are speculated to exert important regulatory functions at the level of gene expression,oncogenesis, and many other pathologies. Hepatitis B virus (HBV) infection is a leading cause of hepatocellularcarcinoma (HCC), and some studies have shown that the expression of non-coding RNAs has an assignable effect onthe development of HBV-induced HCC. In this context, the functions and molecular mechanisms of the HBVinduced non-coding RNA expression in the development of hepatoma have attracted increasing attention. This reviewcovers the progress in the exploration of the relationship between HBV-induced hepatoma and non-coding RNAexpression, cataloging the recent reports about the roles of non-coding RNAs in HBV-induced hepatoma into fiveclasses, including (1) modulation of metabolism in hepatic cancer, (2) aggravation of inflammation and hepaticfibrosis, (3) alteration of the tumor immune microenvironment, (4) non-coding RNA N6-methyladenosinemodification, and a seemingly opposite process, (5) the suppression of the progression of HBV-related HCC. Allevidence supports non-coding RNAs as promising novel targets for the early diagnosis and treatments for HCC.

[学科分类] 仪器

[关键词] Non-coding RNA;Hepatitis B virus;Hepatocellular cancer