Drosophila melanogaster as an indispensable model to decipher the mode of action of neurotoxic compounds"> Drosophila melanogaster as an indispensable model to decipher the mode of action of neurotoxic compounds

[摘要] Exposure to some toxic compounds causes structural and behavioral anomalies associated with the neurons inthe later stage of life. Those toxic compounds are termed as a neurotoxicant, which can be a physical factor, a toxin, aninfection, radiation, or maybe a drug. The incongruities caused due to a neurotoxicant further depend on the toxicity ofthe compound. More importantly, the neurotoxicity of the compound is associated with the concentration and the timepoint of exposure. The neurodevelopmental defect appears depending on the toxicity of the compound. Aneurodevelopmental defect may be associated with a delay in developmental time, defective growth, structuralabnormality of many organs, including sensory organs, behavioral abnormalities, or death in the fetus stage. Numerousmodel organisms are employed to assess the effect of neurotoxicants. The current review summarizes several methodsused to check the effect of neurotoxicant and their effect using the model organism Drosophila melanogaster.

[学科分类] 仪器

[关键词] Developmental cycle;Drug metabolism;Neurotoxicity;Neurotoxicants;Complex behavioral assay;Stress enzymes