in-vivo animal models: Regenerative medicine application in cutaneous wound healing">Mesenchymal stem cells, secretome and biomaterials in in-vivo animal models: Regenerative medicine application in cutaneous wound healing

[摘要] The treatment of nonhealing and chronic cutaneous wounds still needs a clinical advancement to be effective.Both mesenchymal stem cells (MSCs), obtained from different sources, and their secretome derived thereof (especiallyexosomes) can activate signaling pathways related to promotion of cell migration, vascularization, collagen deposition,and inflammatory response demonstrating prohealing, angiogenetic and anti-scarring capacities. On the other hand,biodegradable biomimetic scaffolds can facilitate endogenous cell attachment and proliferation as well as extracellularmatrix production. In this Review, we revise the complex composites made by biomimetic scaffolds, mainly hydrogels,and MSC-derived exosomes constructed for cutaneous wound healing. Studies demonstrate that there exists asynergistic action of scaffolds with encapsulated exosomes, displaying a sustained release profiles to facilitate longlasting healing effects. It can be envisioned that dressings made by biomimetic hydrogels and MSC-derived exosomeswill be clinically applied in the near future for the effective treatment of nonhealing and chronic wounds.

[学科分类] 仪器

[关键词] Biomimetic scaffolds;Cutaneous wound healing;Exosomes;Hydrogels;Mesenchymal stem cells;Secretome