Production of mesenchymal stem cell derived-secretome as cell-free regenerative therapy and immunomodulation: A biomanufacturing perspective

[摘要] The potential of mesenchymal stem cells (MSCs) in regenerative medicine has been largely known due to theircapability to induce tissue regeneration in vivo with minimum inflammation during implantation. This adult stem celltype exhibit unique features of tissue repair mechanism and immune modulation mediated by their secreted factors,called secretome. Recently, the utilization of secretome as a therapeutic agent provided new insight into cell-freetherapy. Nevertheless, a sufficient amount of secretome is necessary to realize their applications for translationalmedicine which required a proper biomanufacturing process. Several factors related to their production need to beconsidered to produce a clinical-grade secretome as a biological therapeutic agent. This viewpoint highlights thecurrent challenges and considerations during the biomanufacturing process of MSCs secretome.

[学科分类] 仪器

[关键词] Secretome;MSCs;Culture system