A potential impact of A Disintegrin and Metalloproteinase DomainLike Protein Decysin-1 (ADAMDEC1) on clear cell renal cell carcinoma propagation

[摘要] Clear cell renal cell carcinoma (KIRC) is the most common and aggressive malignancy subtype of renal neoplasmthat arises from proximal convoluted tubules. It is characterized by poor clinical outcomes and high mortality of patients dueto the lack of specific biomarkers for varying stages of the disease and no effective treatment. Proteases are associated withthe development of several malignant tumors in humans by their ability to degrade extracellular matrices, facilitatingmetastasis. Herein, differentially expressed genes in KIRC cases compared to healthy kidneys were screened out from theGene Expression Profiling Interactive Analysis (GEPIA) database. This data was applied to determine the most elevatedprotease in KIRC and as a result, A Disintegrin and Metalloproteinase Domain-Like Protein Decysin-1 (ADAMDEC1)was selected. This expression pattern was exclusive for KIRC and not observed for papillary and chromophobe renal cellcarcinomas, in which ADAMDEC1 was at the same level in tumors and non-cancer specimens. Furthermore, theADAMDEC1 significant increase was detected in the fourteen other human malignancies compared to healthy samples,which suggested its strong involvement in cancer development. Next, GEPIA and Pathology Atlas correlatedADAMDEC1 high expression with more advanced tumor grade and shorter survival of KIRC patients. Xena FunctionalGenomics Explorer presented that ADAMDEC1 could be hypermethylated in some tumor cases and one somaticmutation in the gene sequence was detected. Finally, a Search Tool for the Retrieval of Interacting Genes/Proteins;STRING base was utilized to predict the interactions of ADAMDEC1 with other molecules and construct the signalingnetwork. In summary, ADAMDEC1 showed the tremendous potential to be the predictive marker for the KIRC and itsdevelopment. Therefore, this review with data analysis can be a good base for further in vitro and in vivo research thatexperimentally can confirm the ADAMDEC1 as prognostic biomarkers and therapeutic target of KIRC.

[学科分类] 仪器

[关键词] A Disintegrin and Metalloproteinase Domain-Like Protein Decysin-1;ADAMDEC1;Clear cell renal cell carcinoma;Patient specimens;Databases