Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR): A critical overview on the most promising applications of molecular scissors in oral medicine

[摘要] The scientific community is continuously working to translate the novel biomedical techniques into effectivemedical treatments. CRISPR-Cas 9 system (Clustered Regularly Interspaced Short Palindromic Repeats-9), commonlyknown as the “molecular scissor”, represents a recently developed biotechnology able to improve the quality and theefficacy of traditional treatments, related to several human diseases, such as chronic diseases, neurodegenerativepathologies and, interestingly, oral diseases. Of course, dental medicine has notably increased the use ofbiotechnologies to ensure modern and conservative approaches: in this landscape, the use of CRISPR-Cas-9 systemmay speed and personalize the traditional therapies, ensuring a good predictability of clinical results. The aim of thiscritical overview is to provide evidence on CRISPR efficacy, taking into specific account its applications in oral medicine.

[学科分类] 仪器

[关键词] Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR);Dentistry;Stem cells