Therapeutic mechanisms and routes of delivery of mesenchymal stem cells in veterinary medicine: A point of view

[摘要] Mesenchymal stem cells (MSCs) represent an important tool in veterinary regenerative medicine due to their ability to home to injury sites and secrete molecules that regulate niches into regenerative microenvironments. Successful cell therapy depends on many factors, including choice of administration route and application of understanding of cell potency and their therapeutic mechanisms. In this point of view, the authors leverage the tumultuous history of the field to demonstrate the need for clinicians to continually update themselves as new discoveries are made in order to avoid misalignments in the future, especially regarding administration routes and dose frequency, as well as to explore recent insights into MSC plasticity, therapeutic mechanisms, and cell delivery systems.

[学科分类] 仪器

[关键词] Cell therapy;Application;Injection;Pharmacodynamics;Pharmacokinetics