Ubiquitin-like posttranslational modifications in NAFLD progression and treatment

[摘要] Nonalcoholic fatty liver disease (NAFLD) is a long-lasting condition that affects the liver, destroying itsfunction. Liver injury can cause steatosis and inflammation, and further activation of hepatic stellate cells (HSCs)often leads to the development of nonalcoholic liver fibrosis. The patient with NAFLD is at risk of developingadvanced liver disease and complications, such as liver failure, hepatocellular carcinoma (HCC), and portalhypertension. Although our understanding of the cellular and molecular mechanisms of NAFLD has greatly improvedin recent years, treatment remains limited. Analysis and characterization of protein posttranslational modifications(PTMs) could improve our understanding of NAFLD pathology and leading to the development of new and moreeffective treatments. In recent years, a number of studies have described how ubiquitin-like (Ubl)-PTMs changeduring NAFLD and how treatments targeting specific enzymes mediating these Ubl-PTMs can improve various liverdiseases, particularly in relation to NAFLD and nonalcoholic liver fibrosis. New strategies for evaluating modifiedproteomes could provide novel insights into the roles of Ubl-PTMs in NAFLD progression and the therapeutic valueof targeting the proteins involved in these Ubl-PTMs.

[学科分类] 仪器

[关键词] NAFLD;Neddylation;Nonalcoholic liver fibrosis;Ubiquitination;SUMOylation