Co-regulator NCOA5 and cancer

[摘要] NCOA5 encodes a co-regulator for estrogen receptors (ERα and ERβ), orphan nuclear receptors (REV-ERBαand REV-ERBβ) and liver X receptor. It can influence many cellular processes by either promoting or inhibiting geneexpression through its two important functional motifs: LxxLL (co-activator) and ΦxxΦΦ (co-repressor). Manyreports have revealed the important roles of NCOA5 in diseases, such as diabetes, reproductive defects andautoimmune disease. In this review, we focus on its function in cancers and summary the current research progressesregarding its different roles in various cancers.

[学科分类] 仪器

[关键词] NCOA5;Co-regulator;Structure and function;Nuclear receptors;Cancer