A nanostructured look of collagen apatite porosity into human mineralized collagen fibril

[摘要] Bone tissue is a hierarchical material characterized at nanoscale by the mineralized collagen fibril, a recurringstructure mainly composed of apatite minerals, collagen and water. Bone nanostructure has a fundamental role indetermining the mechanical behavior of the tissue and its mass transport properties. Diffusion phenomenon allows tomaintain an adequate supply of metabolites in the mechanisms of bone remodeling, adaptation and repair. Severalanalytical and computational models have been developed to analyze and predict bone tissue behavior. However, thefine replication of the natural tissue still represents a challenge. Insights on the structural organization at nanoscaleand on the influence of apatite mineral crystals on the diffusion coefficient lead to outline the functional conditionsfor the development of biomimetic strategies for bone tissue engineering. Thorough understanding of bonenanostructure is essential to improve longevity of bioscaffolds and to decrease the risk of failure by controlling theirmechanical and biological performance.

[学科分类] 仪器

[关键词] Bone nanostructure;Diffusivity;Biomimicking;Bioscaffolds;Tissue engineering