Translational aspects of the modern genetics in head and neck cancers

[摘要] Oral Cancer (OC) is one of the most recurrent cancers in the head and neck squamous cancer (SCCHN)category. Recently, the genome-wide association studies (GWAS) have gained growing interest in the scientificcommunity. GWAS have identified several pathways involved in the interactions among general risk factors andgenomic variants affecting SCCHN. This systematic overview aims to critically evaluate the latest data reported withinthe scientific literature. The aim was to investigate the impact of genetic aspects on SCCHN onset and prognosis,involving other clinical and systemic co-factors. PubMed, Google Scholar, and Cancer Genetics Web databases havebeen systematically investigated for original articles published in the last two years, reporting studies on the mainqueries addressed in this work. This review also comparatively describes the impact of environmental andpathological co-factors in different types of cancers, clarifying and updating the role of genetic factors in SCCHNonset and development. The main outcomes reported may be helpful to drive clinicians towards their clinicalevaluations for the most appropriate therapeutic approach in SCCHN.

[学科分类] 仪器

[关键词] Genome-wide association studies (GWAS);Oral cancer (OC);Oral squamous cell carcinoma (OSCC);OSCC of the head and neck (SCCHN);Oral and pharyngeal cancer (OPC)