HAND2-AS1, PRKAA2 and VLDLR predict the risk of peritoneal metastasis in gastric cancer of different Lauren types based on STEPP analysis

[摘要] The peritoneum is the most common site of recurrence of gastric cancer (GC). Early occult peritonealmetastasis is difficult to detect by imaging examination. Stratifying the risk of peritoneal metastasis in patients withdifferent Lauren subtypes is of great clinical value. We performed a univariate Cox regression to identify those geneswith prognostic value of overall survival (OS) and peritoneal-specified disease-free survival (psDFS) from the GeneExpression Omnibus database. The candidate genes were screened by the Subpopulation Treatment Effect PatternPlot (STEPP) method. Propensity score matching (PSM) analysis was used to reduce the interference of confounderson the results. Based on the optimal cut-off values determined by the STEPP method, we found overexpression ofthree genes (HAND2-AS1, PRKAA2, and VLDLR) was correlated with shorter 1-year psDFS among patients withdiffuse-type than that of patients with intestinal-type GC, and it is highly significant. Gene Set Enrichment Analysis(GSEA) potentially suggested that the three genes promote the early occurrence of peritoneal metastasis in patientswith diffuse-type GC through glucose metabolism-related pathways. These three genes may be potential biomarkers.They can be used to assess the risk of peritoneal metastases to guide treatment decisions and follow-up strategies.

[学科分类] 仪器

[关键词] Peritoneal metastasis;Gastric cancer;Lauren;STEPP