Role of PTX3 and complement modulation in the tumor microenvironment

[摘要] Pentraxin-3 (PTX3), the prototype of long pentraxins, seems to influence complement system (CS) modulation.PTX3 and CS sustain carcinogenesis, enriching tumor microenvironment (TME) with pro-inflammatory moleculespromoting angiogenesis in prostate cancer (PC) and renal cell carcinoma (RCC). Furthermore, cancer cellsoverexpress complement regulatory proteins, such as CD46, CD55 and CD59, which negatively affect complementpathways for support cancer cells survival. This viewpoint aims to elucidate the ambivalent role of PTX3 and the CSin the context of tumor microenvironment (TME).

[学科分类] 仪器

[关键词] Pentraxin-3;Complement system;Tumor microenvironment;Prostate cancer;Renal cell carcinoma