Ferroptosis molecular inducers: A future direction for malignant tumor chemotherapy

[摘要] Iron-dependent ferroptosis is a form of cell death dependent on iron levels. Cells that undergo ferroptosis haveglutathione (GSH) deficiency, reduced Glutathione peroxidase-4 (GPX4) activity and intracellular lipid peroxidation,Mitochondria, lysosomes and many signal pathways are involved in the regulation of ferroptosis. More importantly,many tumor cells resistant to other cell death methods exhibit sensitivity to ferroptosis. Moreover, over recent years, anumber of ferroptosis-induced drugs have been recommended for the treatment of malignant tumors. Therefore, thestudy of ferroptosis is of great significance for future cancer treatments. In this review, we discussed the metabolicprocess of ferroptosis, the role of different organelles, the typical signaling pathways involved in ferroptosis, as well asnatural and synthetic compounds that can induce ferroptosis, aiming to point out new conceptual avenues forutilizing ferroptosis in future cancer treatments.

[学科分类] 仪器

[关键词] Ferroptosis;Cancer;Organelle;Pathways;Ferroptosis-induced drugs