Genetic impact of blood C-reactive protein levels on chronic spinal & widespread pain

[摘要] Purpose Causal mechanisms underlying systemic inflammation in spinal & widespread pain remain an intractable experimental challenge. Here we examined whether: (i) associations between blood C-reactive protein (CRP) and chronic back, neck/shoulder & widespread pain can be explained by shared underlying genetic variants; and (ii) higher CRP levels causally contribute to these conditions.

[学科分类] 骨科学

[关键词] Chronic pain;C-reactive protein;Inflammation biomarkers;Genome-wide association study;Musculoskeletal pain;Genetic predisposition to disease