Loss of lumbar disc height with age and its impact on pain and sensitivity associated behaviors in mice

[摘要] Purpose Aging is a risk factor for several debilitating conditions including those related to chronic back pain and intervertebral disc degeneration, both of which have no cure. Mouse models are useful tools for studying disc degeneration and chronic back pain in a tightly controlled and clinically relevant aging environment. Moreover, mice offer the advantage of carrying out longitudinal studies to understand the etiology and progression of disc pathology induced by genetic or surgical strategies. Previously, age-related behavioral trends of discomfort and enhanced nociception in mice were reported; however, whether these measures are mediated by structural and pathological changes in the disc is unknown.

[学科分类] 骨科学

[关键词] Disc height;Low back pain;Mouse model;Aging;Behavioral study;Allodynia;Mediation;Regression