ISSLS Prize in Bioengineering Science 2023: Age- and sex-related differences in lumbar intervertebral disc degeneration between patients with chronic low back pain and asymptomatic controls

[摘要] Purpose Clinical management of disc degeneration in patients with chronic low back pain (cLBP) is hampered by the challenge of distinguishing pathologic changes relating to pain from physiologic changes related to aging. The goal of this study was to use imaging biomarkers of disc biochemical composition to distinguish degenerative changes associated with cLBP from normal aging.

[学科分类] 骨科学

[关键词] Disc degeneration;Aging;Chronic low back pain;T1ρ (T1rho) magnetic resonance imaging (MRI);Lumbar spine