Calcium pyrophosphate deposition and crowned dens syndrome

[摘要] Calcium pyrophosphate deposition disease (CPDD) was first described in the early 1960s in patients with acute inflammatory arthritis that looked like gout. This was just after the development of the polarized light microscope and before the common use of morphologic or birefringent properties to identify crystal types. Astute clinician-scientists noticed that some of the synovial fluid crystals from patients with goutlike arthritis were resistant to uricase, and later discovered that these uricase-resistant crystals were composed of calcium and pyrophosphate.

[学科分类] 卫生学