SGLT-2 inhibitors are potential game-changers (for more than diabetes)

[摘要] For years there has been discussion about the appropriateness of a glucocentric focus in the management of patients with diabetes. Studies demonstrated the benefit of glucose control on slowing some microvascular complications of diabetes, but the ability to ameliorate renal and particularly cardiovascular events, major causes of morbidity and mortality, has remained elusive. The concern that drugs designed to treat hyperglycemia might be detrimental to cardiovascular health prompted the US Food and Drug Administration to mandate that pharmaceutical sponsors monitor and document cardiovascular safety within their diabetes drug development programs.

[学科分类] 卫生学