Intradermal Hepatitis B Vaccination in Non-responder People Living with Human Immunodeficiency Virus in Japan

[摘要] We performed a pilot study to assess the immunogenicity and safety of intradermal hepatitis B (HB) virus vaccines in people living with HIV (PLWH). This single-center prospective study was conducted in Yokohama, Japan. Adult PLWH with serum antibodies against HB surface antigen (anti-HBs) <10 mIU/mL at all time points after standard HB vaccination were included. We administered HB surface antigen (total dose of 10 μg) at 5 separate sites intradermally at baseline, one month, and 6–9 months and measured anti-HBs 1–3 months after administration. Eleven PLWH were included in this study. The mean age was 36 years, and all patients were men. At baseline, all patients were on antiretroviral therapy, and the mean CD4+ lymphocyte count was 588 /μL and plasma HIV-RNA was 10 mIU/mL in all patients, without serious adverse events.

[学科分类] 传染病学

[关键词] Hepatitis B;HIV;vaccine;intradermal;non-responder