Topical treatments for anal fissure

[摘要] How effective are topical treatments (calcium channel blockers [CCBs], nitrates, and vitamin E) forchronic anal fissures in adults?Bottom lineHealing rates with topical nitroglycerin are roughly60% versus 40% with placebo at 8 weeks. TopicalCCBs are at least as good as nitroglycerin, with alower risk of headache (7% versus 56%). Based on1 RCT, topical vitamin E may be superior to nitroglycerin (86% versus 66% healed at 8 weeks).

[学科分类] 卫生学