Glucose Responsive Insulin Delivery System in Recent Approaches

[摘要] Currently, 382 million individuals worldwide suffer from diabetes mellitus, a chronic medical illness that is brought on by decreased insulinproduction or insulin resistance. The only widely approved therapy for controlling blood glucose levels in diabetic patients is subcutaneousinsulin injection. The blood glucose level must be monitored often in many people with advanced type II diabetes mellitus in order tomaintain the target range. The invasive method of administering long-term insulin therapy, however, creates issues with patient complianceand unexpected drops in blood glucose levels. One technique to get around the issue with the traditional method of administering insulin isto use an artificial closed loop insulin release device that mimics the glucose responsive insulin secretion by pancreatic beta cells. Whencombined with glucose responsive catalyst like glucose oxidase, phenyl boronic acid, and glucose binding proteins, many polymericformulations demonstrated improved glucose responsive release of insulin. The release rate can be regulated by optimizing the concentrationof glucose responsive catalyst.

[学科分类] 药理学