Association of Tetracycline with Hepatotoxicity: A Pharmacovigilance Study

[摘要] Drug Induced Liver Injury (DILI), the most frequent cause of acute liver failure, has grown to be a critical public health issue that cannot beignored. One of the main causes of DILI is antibiotic use. In 45.4% of DILI cases, according to the American DILI Network (DILIN),antibiotics were used. Tetracyclines are frequently prescribed antibacterial medications that have been widely utilised to treat a variety ofinfections. Due to drug resistance, some tetracyclines are no longer used in clinical practise, but others are still crucial. The medications withthe highest antibacterial activity against tetracyclines are doxycycline and minocycline. Tetracyclines, however, can enter the primary andpermanent dentitions and cause discolouration of the bone, cartilage, and teeth. As a result, patients over the age of 8 should only take themajority of tetracyclines.

[学科分类] 药理学