Impact of the Mitochondrion-Toxic Agents on the Cardiovascular System

[摘要] Mitochondrial-toxic agents can cause or worsen cardiovascular disease. Mitochondrion-toxic agents can be classified as having or nothaving a clinical effect, inducing cardiac disease only in humans, only in animals, or both, as prescribed drugs, illegal drugs,exotoxins, nutrients, affecting the heart exclusively or also other organs, being effective only in patients with a mitochondrial disorder orcardiac disease or also in healthy subjects, or being solid, liquid, or volatile agents. In humans, due to mitochondrial dysfunction, thecardiotoxic agents include anthracyclines (particularly doxorubicin), mitoxantrone, cyclophosphamide, fluorouracil, imatinib, cisplatin,bortezomib, trastuzumab, arsenic trioxide, cyclosporine-A, lamotrigine, glycosides, lidocain, isoproterenol, zidovudine, nitroprusside,pivalic acid, alcohol, cocaine, pesticides, cadmium, mycotoxins, cyanotoxins, meat meal, or carbon monoxide. Even more agents only causecardiac abnormalities in animals or tissue due to mitochondrion toxicity.

[学科分类] 药理学