Cancer Recurrence after Surgery and Anesthesia Techniques

[摘要] The effects on cancer cells of many of the most popular anesthetics used in surgical oncology are yet unknown. Due to immuneosuppression, activation of angiogenesis and dispersion of recurrent cancer cells, anesthesia technique may have a varied impact on cancerrecurrence in oncologic patients having surgery. A restriction on the use of volatile anaesthetics; a restriction on the use of opioids becausethese drugs suppress humoral and cellular immunity and their chronic use favours angiogenesis and the development of metastases; and datasupporting the use of intravenous anaesthetics, such as protocol anaesthesia, due to their antitumor protective effects, which inhibitcyclooxygenase 2 and prostaglandins E2 in cancer cells and stimulate the immune response; However, these findings should be interpretedcautiously because there is no evidence that modifying the method anaesthetic is administered can increase the postoperative survival ofcancer patients.

[学科分类] 药理学