The rs2241766, rs266729 and rs1501299 Polymorphisms in ADIPOQ Gene Play Substantial Role in Predisposition to Diabetes

[摘要] One of the most frequent non-communicable diseases in the world is Diabetes Mellitus (DM). Diabetes mellitus affects one out of every eleven persons worldwide (90 percent having type 2 diabetes mellitus). Adiponectin is the most common peptide secreted by adipocytes, and its decline is linked to obesity-related disorders such as insulin resistance, diabetes mellitus, and heart disease. Single Nucleotide Polymorphisms (SNPs) in the adiponectin gene (ADIPOQ) have been linked to diabetes in several meta-analysis studies. The ADIPOQ gene's rs2241766, rs266729 and rs1501299 polymorphisms have been identified as the most prevalent SNPs linked to the development of DM across the formats. Despite the fact that all three SNPs are heavily correlated to DM, two common SNPs rs2241766 and rs266729 are linked to Type 1 Diabetes Mellitus (T1DM), Type 2 Diabetes Mellitus (T2DM) and Gestational Diabetes Mellitus (GDM), whereas rs1501299 is associated with T1DMand T2DM but not with GDM.

[学科分类] 药理学

[关键词] Adiponectin;ADIPOQ gene;Diabetes mellitus;Single nucleotide polymorphism.