Ovarian Metastasis as Initial Presentation of Primary Thyroid Carcinoma: A Case Report and Review of Literature

[摘要] Introduction: Ovarian metastases from thyroid carcinoma are rare. It needs to be differentiated from malignancy occurring in the setting of struma ovarii as the management and prognosis of the two conditions are different. Case Report: A 50-year old lady presented with gradually increasing lower abdominal and low-back pain. Abdominal examination revealed a mass in the left lower quadrant. Histopathology examination of the resected thyroid specimen showed poorly differentiated thyroid carcinoma with immunoreactivity for CK7 and TTF1 but not for CK20, Napsin or WT1. The patient received paclitaxel and carboplatin followed by palliative radiotherapy and I131 therapy. Conclusion: Ovarian metastases from thyroid carcinoma may pose a diagnostic dilemma. Histopathology and immunohistochemical studies are crucial in establishing the diagnosis and management planning.

[学科分类] 生理学

[关键词] Biopsy;Immunohistochemistry;Ovarian Neoplasms;Struma Ovarii;Thyroid Neoplasms.