P2Y12 receptor gene polymorphisms are associated with epilepsy

[摘要] The basic research indicated that microglial P2Y12 receptors (P2Y12Rs) are involved in the pathophysiology of epilepsy through regulated microglial-neuronal interactions, aberrant neurogenesis, or immature neuronal projections. However, whether the clinic case of epilepsy would be associated with P2Y12A may be associated with an increased risk of epilepsy (OR = 0.576, 95% CI = 0.368–0.901, p = 0.015; OR = 0.603, 95% CI = 0.367–0.988, pA genotype and allele frequencies have only a significant difference in female instead of male case (p = 0.004 for genotype; pA genotype might have more frequent seizure (OR = 0.476, 95% CI = 0.255–0.890; p = 0.019). These data implied that both rs1491974 and rs6798347 polymorphisms of P2Y12R would be able to play import roles in epilepsy susceptibility, whereas the rs1491974 polymorphism may be specifically related to seizure frequency.

[学科分类] 分子生物学，细胞生物学和基因

[关键词] P2Y12 receptor;Single-nucleotide polymorphism;Epilepsy